The UNESCO World Heritage-listed centre of Naples rewards exploration, and in addition to the many cultural treasures waiting to be unearthed Neapolitans are rightly proud of their food; this is where you’ll find the best pizza in Italy. The city also acts as a gateway to the fascinating remains of Pompeii and Herculaneum, and the beautiful Amalfi coast.

Situated on the western edge of Sicily, closer to Tunis than it is to Rome, the historic port of Trapani has a discernible North African feel to it. This was once an important medieval trading centre that linked Carthage and Venice, and the lovely old town is a great place to spend some time exploring.

Malta’s tiny capital, established by the Knights of St John, packs in an awful lot of history considering its diminutive size. The atmospheric old streets, bathed in Mediterranean sunshine, are full of attractive honey-golden buildings, along with an impressive selection of bars and restaurants.

The charming port of Agios Nikolaos, on the north east coast of Crete, offers a beguiling blend of characterful tavernas, lively bars and designer boutiques. The town is centred around little Lake Voulismeni, and nearby attractions include some lovely beaches and the Minoan ruins at Gournia.

It's difficult to overstate the spiritual significance of Jerusalem, a holy city to three different faiths: Christianity, Islam and Judaism. Whatever your personal beliefs, it's impossible not to be moved by sights such as the Wailing Wall, the Dome of the Rock and the Church of the Holy Sepulchre.

Haifa is Israel’s third city, a bustling and multicultural place where six different faiths live side by side. The city is the spiritual centre of the Baha’i Faith, and the beautiful Baha’i Gardens are a must-see. Many cruise visitors opt to skip Haifa and take an excursion to Jerusalem and Bethlehem, two to three hours’ drive away.

The buzzing city of Limassol is southern Cyprus’ main port, an important commercial hub that overflows with bars, restaurants and tavernas. It’s also home to a pleasant old town and medieval castle, and serves as an excellent base for exploring the nearby Troodos mountains.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

The Turkish port of Izmir, formerly the Greek city of Smyrna, is a liberal and progressive place where the secularism of Ataturk remains strong. During the Ottoman era this was a melting pot of ethnic groups including Armenians, Jews and Italians, and a cosmopolitan atmosphere persists to this day.