It's difficult to overstate the spiritual significance of Jerusalem, a holy city to three different faiths: Christianity, Islam and Judaism. Whatever your personal beliefs, it's impossible not to be moved by sights such as the Wailing Wall, the Dome of the Rock and the Church of the Holy Sepulchre.

The buzzing city of Limassol is southern Cyprus’ main port, an important commercial hub that overflows with bars, restaurants and tavernas. It’s also home to a pleasant old town and medieval castle, and serves as an excellent base for exploring the nearby Troodos mountains.

Sun-kissed Rhodes, the largest of the Dodecanese islands, is steeped in history; the medieval heart of Rhodes Town was once home to the crusading Knights of St John, and later fell to the Ottoman sultan Suleiman the Magnificent. The hillside village of Lindos, with its pretty whitewashed houses, is another highlight.

The Turkish port of Kusadasi is the gateway to Ephesus, one of the most spectacular archaeological sites in the Eastern Mediterranean. This was the Roman capital of Asia Minor, and the remains constitute the most complete classical city in Europe.

Istanbul is the place where East meets West, where Asia Minor reaches out across the Bosphorus and almost touches Europe, and the city remains a bristling, bustling cultural melting pot, the skyline dotted with magnificent minarets and domes.

Kavala has a rich history dating back nearly 3,000 years, and was known in antiquity as Neapolis. Many of the city’s most interesting sights were built by the Ottomans, including the aqueduct of Suleyman the Magnificent and the beautiful Imaret, a former religious school.

Glamorous Mykonos is the most popular of the Cyclades islands, well known as a haunt of the rich and the famous. It’s also the gateway to the nearby island of Delos, home to one of the most important archaeological sites in Greece.

The volcanic island of Santorini (known officially as Thira) is one of the most spectacularly beautiful in the Mediterranean. The pretty village of Oia, with its whitewashed houses and windmills tumbling down the hillside, is particularly photogenic.

Palermo is an acquired taste; noisy, chaotic and rather grimey in places. But there’s something quite intoxicating about the crumbling facades and the bustling markets, and the Arabesque style of many of the buildings hints at Sicily’s historical role as a stepping stone between Europe and North Africa.

The lovely town of Sorrento, draped across rugged cliffs overlooking the Bay of Naples, has been charming visitors since the days of the Grand Tour. The Renaissance palaces and many craft shops make Sorrento an attractive destination in its own right, and it’s also a jumping off point for Capri, Pompeii and the Amalfi Coast.